Household peanut consumption as a risk factor for the development of peanut allergy Adam T. Fox, FRCPCH, Peter Sasieni, PhD, George du Toit, FRCPCH, Huma.

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Presentation transcript:

Household peanut consumption as a risk factor for the development of peanut allergy Adam T. Fox, FRCPCH, Peter Sasieni, PhD, George du Toit, FRCPCH, Huma Syed, PhD, Gideon Lack, FRCPCH Journal of Allergy and Clinical Immunology Volume 123, Issue 2, Pages 417-423 (February 2009) DOI: 10.1016/j.jaci.2008.12.014 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Levels of peanut exposure by different routes during first year of life in cases and controls. Maternal peanut consumption during pregnancy = average weekly peanut protein consumed by mother during course of entire pregnancy. Maternal peanut consumption during lactation = average weekly peanut protein consumed by mother during lactation. Infant consumption during first year of life = average weekly peanut protein consumed by infant over their entire first year of life (derived from age at first exposure and regular consumption from that point). Environmental exposure = average weekly peanut protein consumed by all family members living in the household during first year of life. Maternal component based on appropriately weighted composite of her consumption during lactation and during period of first year of life after breast-feeding has ceased. Journal of Allergy and Clinical Immunology 2009 123, 417-423DOI: (10.1016/j.jaci.2008.12.014) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Proportion of allergic children with peanut allergy (A) as a function of household peanut consumption during infancy, and (B) as a function of maternal peanut consumption during pregnancy (grams of peanut protein per week). A, 1, and B, 1: All children with food allergy (n = 293). A, 2, children with no maternal consumption in pregnancy (n = 134). B, 2, Children with no household consumption during infancy (n = 66). A, 3, Children with maternal consumption of >7 g peanut protein per week during pregnancy (n = 66). B, 3, Children with household consumption of >7 g peanut protein per week during infancy (n = 152). Journal of Allergy and Clinical Immunology 2009 123, 417-423DOI: (10.1016/j.jaci.2008.12.014) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Odds ratio of PA according to source of peanut protein. Journal of Allergy and Clinical Immunology 2009 123, 417-423DOI: (10.1016/j.jaci.2008.12.014) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Peanut allergy among children with food allergy (n = 293) as a function of environmental exposure depending on whether child first ate peanuts by 12 months. Journal of Allergy and Clinical Immunology 2009 123, 417-423DOI: (10.1016/j.jaci.2008.12.014) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions