Plaque area remained increased in the previously hyperglycemic mice.

Slides:

Advertisements

Similar presentations

$100 $200 $300 $400 $500 $100 $200 $300 $400 $500 $100 $200 $300 $400 $500 $100 $200 $300 $400 $500 $100 $200 $300 $400 $500 $100 $200 $300.

Advertisements

Baseline Patient Characteristics Bart A.N. Verhoeven, et al. Stroke 2006;37:

Time Remaining 20:00.

Atherosclerotic lesion area within the aortic sinus of apoE - / - and apoE - / - - hCRP + mice Gideon M. Hirschfield et al. PNAS 2005;102:8309– 8314.

DOI: /j.atherosclerosis

Functions of microRNA-33a/b and microRNA therapeutics

Assessment of Unstable Atherosclerosis in Mice

Circ Cardiovasc Imaging

Molecular Imaging of Atherosclerotic Plaques Using a Human Antibody Against the Extra-Domain B of Fibronectin by Christian M. Matter, Pia K. Schuler, Patrizia.

Atorvastatin 20 mg (n=25 lesions) Atorvastatin 5 mg (n=25 lesions)

Figure 6. Representative micrographs showing macrophages and nitrotyrosine in atherosclerotic plaques in aortic root cross-sections from apo-E −/− mice.

Figure 3. Severity of aortic atherosclerosis in apo-E −/− mice with CRF. Aortic plaque area fraction (A), aortic cholesterol content (B), and aortic root.

Figure 2. Plasma lipoprotein cholesterol in apo-E −/− mice with CRF

Figure 1. Plasma urea concentrations in apolipoprotein E–deficient (apo-E −/−) mice with chronic renal failure (CRF). Figure 1. Plasma urea concentrations.

Expression of IL-1α in goblet cells and their destruction during DSS-induced colitis. Expression of IL-1α in goblet cells and their destruction during.

INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.

(red) & endothelium (green) PMCA4 (green) & DAPI (blue)

Histological changes in mouse colons after DSS treatment.

Rena Watanabe et al. BTS 2016;1:

LXs reverse established DKD. (A) Study design overview.

FGFR1 and TGFβ signaling activity in smooth muscle cells in a mouse atherosclerosis model FGFR1 and TGFβ signaling activity in smooth muscle cells in a.

Targeted disruption of the RapGEF2 gene.

Fig. 2. CD treatment facilitates regression of murine atherosclerosis.

Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. Representative histological images of aorta from WT, ApoEm/m and ApoE−/−

Diabetic FXR KO kidney showed increased lipid accumulation.

INT-747 treatment showed antifibrotic, anti-inflammatory, and antioxidative effects on diabetic DBA/2J mice. INT-747 treatment showed antifibrotic, anti-inflammatory,

Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

Left: Baseline brain white and gray matter uptake rates of [18F]-FTHA (A) and [11C]-palmitate (B). Left: Baseline brain white and gray matter uptake rates.

A: Total collagen content by Sirius red staining in cardiac tissue of control (SD) animals. A: Total collagen content by Sirius red staining in cardiac.

Analysis of peripheral blood CD4+CD25+ T-cells after B6

Immunoperoxidase stainings for HLA-DR (A and B) and HLA-DP (C and D) in jejunal biopsy specimens from a healthy control (A and C) and from a type 1 diabetic.

Predicted percentage of home discharge by diabetes group adjusting for all variables listed in the age-centered logistic regression model with examination.

Significant pathological changes and activation of Nrf2 pathway in the glomeruli of human diabetic nephropathy patients. Significant pathological changes.

Glucose infusion rate required to maintain the hyperglycemic clamp during the experimental period in sedentary and exercised dogs receiving basal or elevated.

Flow cytometry of subcutaneous adipose tissue stromovascular cells.

Sox4 promotes hepatic TG accumulation in vivo.

Glycemia and glucose tolerance of RIP-N mice.

Fragment N expression does not affect islet morphology and cellularity

Pericentrin expression in human and murine tissues.

Glucose tolerance in WT and TRPM2-KO mice.

Transgenic restoration of long-chain n-3 PUFA protects against obesity-linked insulin resistance and glucose intolerance. Transgenic restoration of long-chain.

Effect of berberine on white adipose tissue mass.

ΑGLP-1R−/− mice show glucose intolerance and disturbed glucagon secretion in response to i.p. glucose administration. αGLP-1R−/− mice show glucose intolerance.

FFAs have differential effects on NFκB translocation and ROS generation. 3T3–L1 adipocytes differentiated in 5 or 25 mmol/l glucose were cultured on glass.

E11 pancreas cultured for 6 days in the presence of morpholine-ring antisense against GIP, GIPR, or control. E11 pancreas cultured for 6 days in the presence.

The effect of VSG on body weight and body fat in GLP-1r KO mice.

Higher levels of PEDF-impaired skin structure and function.

AgRP-ATF4 KO mice have decreased food intake and enhanced energy expenditure. AgRP-ATF4 KO mice have decreased food intake and enhanced energy expenditure.

COX-2 deletion in macrophages led to increased renal macrophage infiltration in diabetic mice. COX-2 deletion in macrophages led to increased renal macrophage.

Effect of PEDF+DHA treatment on wound healing in diabetic corneas.

Atrasentan reduces albuminuria in diabetic apoE KO mice.

Mechanism of action of the novel immunomodulatory regimen tested in islet transplantation in NOD mice. Mechanism of action of the novel immunomodulatory.

Effect of PP on AT morphology and inflammation after 3 days of treatment. Effect of PP on AT morphology and inflammation after 3 days of treatment. A:

Characterization of LDLR−/− control and Western-diet offspring at birth and at 90 days of age. Characterization of LDLR−/− control and Western-diet offspring.

Matthias Nahrendorf et al. JIMG 2009;2:

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.

Association of ISI with all-cause mortality as modeled by cubic spline, adjusted for age, sex, race, and study site, among 3,138 participants in the CHS.

Functional and histological examinations of diabetic EC-PKCβ2Tg and WT mice. Functional and histological examinations of diabetic EC-PKCβ2Tg and WT mice.

Urinary albumin excretion and histology of glomeruli.

Energy stores in quadriceps muscles at rest (white bars) and after treadmill exercise (black bars) in WT and HSL KO mice. Energy stores in quadriceps muscles.

Glucose-stimulated insulin secretion, plasma glucagon levels, and pancreatic hormone contents. Glucose-stimulated insulin secretion, plasma glucagon levels,

Expression of PKCδ in islets and other tissues of control and PKCδKN-overexpressing mice. Expression of PKCδ in islets and other tissues of control and.

SP promotes corneal epithelial wound healing and restores corneal sensitivity in diabetic mice. SP promotes corneal epithelial wound healing and restores.

Morphologic changes induced in immortalized human podocytes after treatment with TGF-β1 (10 ng/mL, right) for 3 days when compared with control cells (left),

Expression and function of fragment N in RIP-N mice.

Increased pancreatic insulin content and islet size and protection against HFD- and palmitate-induced cell death in PKCδKN-overexpressing mice. Increased.

Apoptosis in CAM vessels after staining with TUNEL

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

Suppression by nobiletin of TPA-induced skin morphological changes observed by H&E staining. Suppression by nobiletin of TPA-induced skin morphological.

Presentation transcript:

Plaque area remained increased in the previously hyperglycemic mice. Plaque area remained increased in the previously hyperglycemic mice. Atherosclerotic plaques in aorta staining in red with picro sirus red solution in control apoE KO (A), diabetic apoE KO (B), and previously hyperglycemic apoE KO mice (C). ABDOM, abdominal; THOR, thoracic. (A high-quality digital representation of this figure is available in the online issue.)‏ Daniella Brasacchio et al. Diabetes 2009;58:1229-1236 ©2009 by American Diabetes Association