Fig. 2. GCE induces allergic inflammation in the mouse model of asthma

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Fig. 2. GCE induces allergic inflammation in the mouse model of asthma Fig. 2. GCE induces allergic inflammation in the mouse model of asthma. (A) BHR is significantly increased following GCE treatment and suppressed following PAR2-ant and NAC treatment. ‡P < 0.001 compared to saline. (B) The total number of cells in bronchoalveolar lavage fluid is also significantly increased following GCE treatment and suppressed following PAR2-ant and NAC treatment. (C) The numbers of macrophages, eosinophils and neutrophils are significantly increased following GCE treatment and suppressed following PAR2-ant and NAC treatment. (D) The total immunoglobulin E level is also significantly increased following GCE treatment and suppressed following PAR2-ant and NAC treatment. (E) Lung inflammation (hematoxylin and eosin staining 200 × magnification) and (F) peribronchial inflammation is significantly increased following GCE treatment and suppressed following PAR2 and NAC treatment. BHR, bronchial hypersensitivity; GCE, German cockroach extract; CE, cockroach extract; NAC, N-acetylcysteine; PAR2-ant, protease-activated receptor 2-antagonist. *P < 0.05, †P < 0.01, and ‡P < 0.001. The experiments were repeated 5 times. Fig. 2. GCE induces allergic inflammation in the mouse model of asthma. (A) BHR is significantly increased following GCE treatment and suppressed following PAR2-ant and NAC treatment. ‡P < 0.001 compared to saline. (B) The total number of cells in bronchoalveolar lavage fluid is also significantly increased following GCE treatment and suppressed following… Allergy Asthma Immunol Res. 2019 Jul;11(4):560-571. https://doi.org/10.4168/aair.2019.11.4.560