Fig. 1 Cancer cell lines exhibiting homozygous deletion of MTAP show altered patterns of metabolite levels. Cancer cell lines exhibiting homozygous deletion.

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Presentation transcript:

Fig. 1 Cancer cell lines exhibiting homozygous deletion of MTAP show altered patterns of metabolite levels. Cancer cell lines exhibiting homozygous deletion of MTAP show altered patterns of metabolite levels. (A) Methionine cycle. Methionine can be recycled from homocysteine via a donation from serine or glycine or salvaged by MTAP via conversion of the polyamine biosynthesis by-product MTA. SAM, s-adenosyl-methionine; SAH, s-adenosyl-homocysteine. (B) Cancer cell line panel of 10 lines from five different tissues, exhibiting either wild-type or homozygous deletion of p16/MTAP. Western blot validation of MTAP deletion. (C) Integrated intensity values (relative metabolite abundance) of MTA in MTAP+/+ versus MTAP−/− cell lines. P values were obtained from Student’s t test. (D) Heat map of top 50 differential metabolites between MTAP+/+ and MTAP−/− cell lines. Top affected pathways are indicated. (E) PCA of variance between MTAP+/+ and MTAP−/− groups. (F) Assignment of principal component (PC) that displays greatest variance between the indicated groups. AUC, area under the curve. Sydney M. Sanderson et al. Sci Adv 2019;5:eaav7769 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).