Contaminants in Commercial Preparations of Melatonin

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Presentation transcript:

Contaminants in Commercial Preparations of Melatonin Brian L. Williamson, Ph.D., Andrew J. Tomlinson, Ph.D., Stephen Naylor, Ph.D., Gerald J. Gleich, M.D. Mayo Clinic Proceedings Volume 72, Issue 11, Pages 1094-1095 (November 1997) DOI: 10.1016/S0025-6196(11)63555-6 Copyright © 1997 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Chemical structures of contaminants detected in eosinophilia-myalgia syndrome (EMS)-associated L-tryptophan (L-Trp) and in commercial preparations of melatonin. “Peak E” contaminant from EMS-associated L-Trp (A). Formaldehyde-melatonin condensation product (B), structural isomers of hydroxymelatonin (C and D), and peak E analogue (E) detected in random samples of melatonin. Mayo Clinic Proceedings 1997 72, 1094-1095DOI: (10.1016/S0025-6196(11)63555-6) Copyright © 1997 Mayo Foundation for Medical Education and Research Terms and Conditions