A nest in renal fibrosis?

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Presentation transcript:

A nest in renal fibrosis? J.-L. Bascands, J. Klein, J.P. Schanstra Kidney International Volume 72, Issue 3, Pages 242-244 (August 2007) DOI: 10.1038/sj.ki.5002331 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Renal nestin expression under normal and pathological conditions. During embryogenesis, nestin progenitor cells are expressed in the metanephric mesenchyme mainly in the vascular cleft of the S-shaped body and in the vascular tuft of immature glomeruli of the capillary loop stage. In the newborn, transient nestin expression is localized in proximal tubular cells. In the adult kidney, nestin is expressed only in glomeruli — more precisely, in glomerular podocytes. Under pathological conditions, depending on the injury type, renal nestin upregulation can be observed in podocytes, and de novo nestin expression was observed in some tubular cells and myofibroblasts in areas with severe tubular damage and interstitial fibrosis.2,6 Question marks indicate that the origin of the nestin-positive myofibroblasts remains to be clearly established. EMT, epithelial-to-mesenchymal transition. Kidney International 2007 72, 242-244DOI: (10.1038/sj.ki.5002331) Copyright © 2007 International Society of Nephrology Terms and Conditions