Ascorbic Acid Deficiency Leads to Epidermal Atrophy and UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice Yasunori Sato, Koji Y. Arai,

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Ascorbic Acid Deficiency Leads to Epidermal Atrophy and UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice Yasunori Sato, Koji Y. Arai, Toshio Nishiyama, Yoshihiro Nomura, Yuki Kishimoto, Shingo Aizawa, Naoki Maruyama, Akihito Ishigami Journal of Investigative Dermatology Volume 132, Issue 8, Pages 2112-2115 (August 2012) DOI: 10.1038/jid.2012.105 Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Effects of ascorbic acid (AA) deficiency on AA and dehydroascorbic acid content and UVB-induced skin pigmentation. (a) Representative photograph of devil mice. (b) Body-weight changes (difference from the mean body weight at week 0) of all four groups. Values are expressed as means±SEM of five animals. *P<0.01, **P<0.05 compared with AA (+) and UVB AA (+) groups. ††P<0.05 difference between UVB AA (+) and UVB AA (-) groups. (c) AA (closed column) and dehydroascorbic acid (open column) contents in the skin. Values are expressed as means±SEM of five animals. (d) Time course of L* value (a measure of skin lightness). Values are expressed as means±SEM of five animals. *P<0.01 compared with AA (+) and AA (-) groups. †P<0.01 compared with UVB AA (+) group. (e) Representative photographs of dorsal skin after UVB exposure for 4 and 8 weeks. (f) Fontana–Masson staining of dorsal skin specimens after UVB exposure for 8 weeks. Arrows indicate melanin pigment. Der., dermis; Epi., epidermis; N.D., not detected. (e) Bar=1mm, (f) bar=10μm. Journal of Investigative Dermatology 2012 132, 2112-2115DOI: (10.1038/jid.2012.105) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Effects of AA deficiency on epidermal morphology. (a) High magnification of the epidermis from the skin of all four groups is shown. (b) Epidermal thickness in hematoxylin–eosin (HE)-stained sections was measured as the distance between the top of the basement membrane and the bottom of the stratum corneum at five randomly selected fields from each animal. Values are expressed as means±SEM of five animals. (c) Immunofluorescence staining of involucrin, filaggrin, loricrin, keratin 14, and collagen type IV. AA, ascorbic acid; Der., dermis; Epi., epidermis. Bar=20μm. Journal of Investigative Dermatology 2012 132, 2112-2115DOI: (10.1038/jid.2012.105) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions