Anne M. Fitzpatrick, PhD, Youngja Park, PhD, Lou Ann S

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Presentation transcript:

Children with severe asthma have unique oxidative stress–associated metabolomic profiles Anne M. Fitzpatrick, PhD, Youngja Park, PhD, Lou Ann S. Brown, PhD, Dean P. Jones, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 1, Pages 258-261.e8 (January 2014) DOI: 10.1016/j.jaci.2013.10.012 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Analysis of identified m/z features by using partial least squares discriminant analysis with orthogonal signal correction demonstrates complete separation of the groups. Replicate values (averaged from triplicate analysis) are shown for each subject as a circle (mild-to-moderate asthma) or square (severe asthma). B, Manhattan plot demonstrating significantly different m/z features (individual points) between children with mild-to-moderate asthma and severe asthma. Journal of Allergy and Clinical Immunology 2014 133, 258-261.e8DOI: (10.1016/j.jaci.2013.10.012) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Distribution of 164 identified human compounds (FDR q = 0.01) across the KEGG metabolic pathway (accessible at http://www.genome.jp.jp/kegg/). Each black dot corresponds to an identified compound. Journal of Allergy and Clinical Immunology 2014 133, 258-261.e8DOI: (10.1016/j.jaci.2013.10.012) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Serine, glycine, and threonine metabolism. THF, Tetrahydrofolate. Journal of Allergy and Clinical Immunology 2014 133, 258-261.e8DOI: (10.1016/j.jaci.2013.10.012) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions