Impact of low-level galactose exposure on acute and long-term outcomes in GALT-null Drosophila. Impact of low-level galactose exposure on acute and long-term.

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Impact of low-level galactose exposure on acute and long-term outcomes in GALT-null Drosophila. Impact of low-level galactose exposure on acute and long-term outcomes in GALT-null Drosophila. (A) Survival of GALT-null and control (GALT+) larvae to adulthood when raised on food containing 555 mM glucose with or without 50 mM galactose (gal). These differences were not significant (P>0.05; both comparisons). (B) Climbing ability of adult flies reared at 28°C in the presence versus absence of 50 mM dietary galactose. This low level of dietary galactose exposure had no apparent impact on climbing ability of GALT+ flies and slightly improved climbing ability of the GALT-null flies (P=0.048). (C) Fecundity of female flies reared and tested at 28°C in the presence versus absence of 50 mM dietary galactose. We saw no significant impact of low-level galactose exposure on female fecundity of control animals (P>0.05) or GALT-null animals (P>0.05). Values plotted represent mean±s.e.m.; the number of cohorts tested for each genotype (n) is indicated on the figure. P-values were calculated using an effects model, as described in Materials and Methods, and a t-test for pair-wise comparisons. Jennifer M. I. Daenzer et al. Dis. Model. Mech. 2016;9:1375-1382 © 2016. Published by The Company of Biologists Ltd