T-Cell Receptor Gene Therapy: Critical Parameters for Clinical Success Carsten Linnemann, Ton N.M. Schumacher, Gavin M. Bendle  Journal of Investigative Dermatology  Volume 131, Issue 9, Pages 1806-1816 (September 2011) DOI: 10.1038/jid.2011.160 Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Milestones in the development of TCR gene therapy. NIH, National Institutes of Health; PBLs, peripheral blood lymphocytes; TCR, T-cell receptor. Journal of Investigative Dermatology 2011 131, 1806-1816DOI: (10.1038/jid.2011.160) Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Formation of mixed-TCR dimers upon TCR gene transfer. The introduction of a new TCR into a T cell can lead to pairing of endogenous and introduced TCR chains. Theoretically, two new TCRs consisting of one endogenous and one introduced TCR chain can be formed. Problematically, the specificity of these mixed-TCR dimers cannot be predicted and may lead to autoreactivity. TCR, T-cell receptor. Journal of Investigative Dermatology 2011 131, 1806-1816DOI: (10.1038/jid.2011.160) Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Potential future milestones in the clinical development of TCR gene therapy. TCR, T-cell receptor. Journal of Investigative Dermatology 2011 131, 1806-1816DOI: (10.1038/jid.2011.160) Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions