Mouse lymphoma model. Mouse lymphoma model. A, EL-Arf−/− cells (1 × 106) were tail-vein injected into C57BL/6 mice. LNIWC imaging was separated into 2.

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Mouse lymphoma model. Mouse lymphoma model. A, EL-Arf−/− cells (1 × 106) were tail-vein injected into C57BL/6 mice. LNIWC imaging was separated into 2 groups: group I was focused on from day 0 to 10, and for group II from day 11 to 17. This was done because of the limitation of repeatedly opening the staples up to 6 to 7 times in the same mouse. N = 7 mice were imaged with IVM in each group in 6 independent experiments. B, tumor development in the ILN. Symbols represent the means of ILN volumes determined by N = 3 to 7 animals for each point. Bars, SEM; *, P < 0.05. C, representative images of the ILN on days 7, 14, and 21 postinjection. Ken Ito et al. Cancer Res 2012;72:6111-6118 ©2012 by American Association for Cancer Research