Morphine Bioavailability from a Topical Gel Formulation in Volunteers Judith A. Paice, PhD, RN, Jamie H. Von Roenn, MD, J. Craig Hudgins, BS, Lynn Luong, BS, Tom C. Krejcie, MD, Michael J. Avram, PhD  Journal of Pain and Symptom Management  Volume 35, Issue 3, Pages 314-320 (March 2008) DOI: 10.1016/j.jpainsymman.2007.04.016 Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Venous plasma morphine concentration histories for 600minutes after subcutaneous administration of 3mg of morphine to Subject 2. The circles represent the measured morphine concentrations while the line represents concentrations predicted by the two-compartment model. Following topical administration of 10mg morphine compounded in a PLO base for transdermal drug delivery, morphine was detectable but below the limit of quantitation (0.5ng/mL) in only three samples, obtained 60, 75, and 90minutes after topical drug administration, from this subject. The inverted triangles represent the times at which morphine was detected, but below the limit of quantification, after topical administration. Journal of Pain and Symptom Management 2008 35, 314-320DOI: (10.1016/j.jpainsymman.2007.04.016) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions