MS, Age, and Immune Function

Immunosenescence Thymic Involution

Immunosenescence Natural Aging of the Immune System

Immunosenescence Response to Pathogens

Immunosenescence and MS

Incidence of Herpes Zoster Across Different DMTs in Patients With MS

Immunosenescence Risk of Infection Increases With Age

Impact of Age in MS

Patients With MS Seen in Practice Differ From Patients in Clinical Trials

Window of Therapeutic Efficacy in MS Is It Relevant?

Role of Inflammation

Brain Aging in the General Population WMH Increases With Age

Brain Aging in the General Population BVL Increases With Age

MS Treatment Strategies Maintenance vs IRT

MS Treatment Strategies Treat-2-Target NEDA Algorithm

Treatment Implications When Considering Age Maintenance vs IRT

Vascular Comorbidity Accelerates Disability Progression in MS

Monitoring Immunosenescence

Concluding Remarks

Abbreviations

Abbreviations (cont)