Volume 63, Issue 1, Pages (January 2003)

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Volume 63, Issue 1, Pages 107-112 (January 2003) Hypercholesterolemia is a prerequisite for puromycin inducible damage in mouse kidney Zhu-Zhu Cheng, Anu Pätäri, Katriina Aalto-Setälä, Dmitry Novikov, Detlef Schlöndorff, Harry Holthöfer Kidney International Volume 63, Issue 1, Pages 107-112 (January 2003) DOI: 10.1046/j.1523-1755.2003.00726.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Urinary albumin concentrations in the apoE group-2 mice (high cholesterol diet), 3 and 8 days after the puromycin injection. Symbols are: (□) control; () puromycin; () puromycin + probucol; () probucol. Data are presented as means ± SD. *P < 0.01. Kidney International 2003 63, 107-112DOI: (10.1046/j.1523-1755.2003.00726.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Immunohistochemistry for malonyldialdehyde (MDA) in the puromycin treated (a) and control (b) mouse glomeruli of the apoE group-2 (high cholesterol diet). Note the prominent mesangial reactivity in panel a. Kidney International 2003 63, 107-112DOI: (10.1046/j.1523-1755.2003.00726.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Amount of nephrin-specific mRNA in the apoE group-2 (high cholesterol diet) as determined by real time reverse transcription-polymerase chain reaction (RT-PCR) and normalized with the respective GAPDH mRNA. Symbols are: (□) control; () puromycin; () puromycin + probucol; () probucol. The mean of each subgroup ± SD is shown. Kidney International 2003 63, 107-112DOI: (10.1046/j.1523-1755.2003.00726.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Immunofluorescence staining of mouse glomeruli from apoE group-2 (high cholesterol diet) with anti-nephrin antibody. The control tissue (a) shows a strong epithelial staining pattern in the glomerulus, while only very weak reactivity is seen in the puromycin treated kidney (b). Kidney International 2003 63, 107-112DOI: (10.1046/j.1523-1755.2003.00726.x) Copyright © 2003 International Society of Nephrology Terms and Conditions