USP2a regulates MYC expression through the MDM2–p53 axis.

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USP2a regulates MYC expression through the MDM2–p53 axis. USP2a regulates MYC expression through the MDM2–p53 axis. A, kinetics profile (0– hours) of protein levels in LNCaP cells after pUSP2aWT (purple bars) overexpression or empty vector (green bars). Representative blots are shown at each set point for the specific protein (upper panel) and actin levels (lower panel). B, miR-34b/c expression profile under the same conditions depicted in A. Barbara Benassi et al. Cancer Discovery 2012;2:236-247 ©2012 by American Association for Cancer Research