GPCR Signaling: β-arrestins Kiss and Remember Ravi Ranjan, Pragya Gupta, Arun K. Shukla  Current Biology  Volume 26, Issue 7, Pages R285-R288 (April 2016) DOI: 10.1016/j.cub.2016.02.056 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Diverse patterns of β-arrestin-mediated ERK activation downstream of GPCRs. (A) For class A receptors, agonist stimulation leads to β-arrestin translocation to the plasma membrane, colocalization and internalization of the receptor–β-arrestin complex and ERK activation. β-arrestin interaction with the receptor is transient: it dissociates from the internalized complex followed by rapid recycling of the receptor to the plasma membrane. (B) Class B receptors are associated with β-arrestin more robustly, internalize with β-arrestin and are targeted to endosome as a stable complex with β-arrestin. (C) β1AR exhibits a pattern that is distinct from both class A and B receptors, whereby β-arrestin 2, after its brief encounter with activated receptor, is localized in clathrin-coated structures at the plasma membrane and triggers ERK activation. β1AR does not colocalize with β-arrestin 2 in these structures [7]. Current Biology 2016 26, R285-R288DOI: (10.1016/j.cub.2016.02.056) Copyright © 2016 Elsevier Ltd Terms and Conditions