Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q Matthew B.

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Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q Matthew B. McQueen, B. Devlin, Stephen V. Faraone, Vishwajit L. Nimgaonkar, Pamela Sklar, Jordan W. Smoller, Rami Abou Jamra, Margot Albus, Silviu-Alin Bacanu, Miron Baron, Thomas B. Barrett, Wade Berrettini, Deborah Blacker, William Byerley, Sven Cichon, Willam Coryell, Nick Craddock, Mark J. Daly, J. Raymond DePaulo, Howard J. Edenberg, Tatiana Foroud, Michael Gill, T. Conrad Gilliam, Marian Hamshere, Ian Jones, Lisa Jones, Suh-Hang Juo, John R. Kelsoe, David Lambert, Christoph Lange, Bernard Lerer, Jianjun Liu, Wolfgang Maier, James D. MacKinnon, Melvin G. McInnis, Francis J. McMahon, Dennis L. Murphy, Markus M. Nöthen, John I. Nurnberger, Carlos N. Pato, Michele T. Pato, James B. Potash, Peter Propping, Ann E. Pulver, John P. Rice, Marcella Rietschel, William Scheftner, Johannes Schumacher, Ricardo Segurado, Kristel Van Steen, Weiting Xie, Peter P. Zandi, Nan M. Laird The American Journal of Human Genetics Volume 77, Issue 4, Pages 582-595 (October 2005) DOI: 10.1086/491603 Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 1 Relative contribution of component data sets to the pooled linkage signals. The LOD scores from the pooled analysis (solid black line) are overlaid with the LOD scores from the data set–specific analysis (the horizontal dotted line indicates the genomewide significance threshold). A, Narrow BP phenotype, chromosome 6. B, Broad BP phenotype, chromosome 8. BONN=Bonn; COLU=Columbia; JHU1=Johns Hopkins 1; JHU2=Johns Hopkins 2; NIW1=NIMH Wave 1; NIW2=NIMH Wave 2; NIW3=NIMH Wave 3; NIW4=NIMH Wave 4; PORT=Portuguese; UCSD=UCSD; WELL=Wellcome Trust; POOL=pooled sample. The American Journal of Human Genetics 2005 77, 582-595DOI: (10.1086/491603) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 2 IBDm and 95% CIs for the component data sets, as well as the random-effects summary point estimate. A, Narrow BP phenotype, chromosome 6 at 115 cM. B, Broad BP phenotype, chromosome 8 at 151 cM. BONN=Bonn; COLU=Columbia; JHU1=Johns Hopkins 1; JHU2=Johns Hopkins 2; NIW1=NIMH Wave 1; NIW2=NIMH Wave 2; NIW3=NIMH Wave 3; NIW4=NIMH Wave 4; PORT=Portuguese; UCSD=UCSD; WELL=Wellcome Trust; SUMM=random-effects summary IBDm. The American Journal of Human Genetics 2005 77, 582-595DOI: (10.1086/491603) Copyright © 2005 The American Society of Human Genetics Terms and Conditions