B. C. Fleming, H. L. Oksendahl, W. A. Mehan, R. Portnoy, P. D

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Delayed Gadolinium-Enhanced MR Imaging of Cartilage (dGEMRIC) following ACL injury B.C. Fleming, H.L. Oksendahl, W.A. Mehan, R. Portnoy, P.D. Fadale, M.J. Hulstyn, M.E. Bowers, J.T. Machan, G.A. Tung Osteoarthritis and Cartilage Volume 18, Issue 5, Pages 662-667 (May 2010) DOI: 10.1016/j.joca.2010.01.009 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 The median slice through the medial femoral condyle was selected for dGEMRIC analysis. Both the tibial and femoral cartilage segments were then evaluated within this slice. Osteoarthritis and Cartilage 2010 18, 662-667DOI: (10.1016/j.joca.2010.01.009) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 T1 maps were generated of the medial compartment of the tibia and the femur using the MRIMapper software package, and the mean dGEMRIC indices were calculated. The blue and red regions denote high and low GAG concentrations, respectively. Osteoarthritis and Cartilage 2010 18, 662-667DOI: (10.1016/j.joca.2010.01.009) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Mean dGEMRIC indices from the mid-sagittal slice of the medial compartment of the tibia and femur. The dGEMRIC indices of the ACL-injured knees were significantly less than those of the contralateral uninjured knees (P=0.007). The indices between the tibia and femur were not significantly different (P=0.800). There was no significant difference due to imaging order (P=0.439). The dotted line represents the upper threshold from patients with radiographic evidence of OA25. Osteoarthritis and Cartilage 2010 18, 662-667DOI: (10.1016/j.joca.2010.01.009) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 The medial compartment dGEMRIC indices for the ACL-injured (closed circles) and the contralateral control knee (open circles) are shown for all subjects. For each pair, the dGEMRIC index for the injured knee is less than that of the uninjured knee. The regression line and the associated 95% confidence intervals for the injured knees are also shown. The lower dGEMRIC index remains relatively constant over time. Osteoarthritis and Cartilage 2010 18, 662-667DOI: (10.1016/j.joca.2010.01.009) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions