Favorable balance of prostacyclin and thromboxane A2 improves early patency of human in situ vein grafts Harry L. Bush, M.D., John N. Graber, M.D., Joseph.

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Presentation transcript:

Favorable balance of prostacyclin and thromboxane A2 improves early patency of human in situ vein grafts Harry L. Bush, M.D., John N. Graber, M.D., Joseph A. Jakubowski, Ph.D., Suchen L. Hong, Ph.D., Melissa McCabe, B.S., Daniel Deykin, M.D., Donald C. Nabseth, M.D. Journal of Vascular Surgery Volume 1, Issue 1, Pages 149-159 (January 1984) DOI: 10.1016/0741-5214(84)90194-0 Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 1 Vein graft perfusion system. P = pressure; Q = flow; T = temperature. Journal of Vascular Surgery 1984 1, 149-159DOI: (10.1016/0741-5214(84)90194-0) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 2 Cumulative graft patency for 49 in situ saphenous vein below-knee bypasses for limb salvage (life-table method). Journal of Vascular Surgery 1984 1, 149-159DOI: (10.1016/0741-5214(84)90194-0) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 3 Endogenous prostacyclin production by in situ—and reversed-treated human saphenous vein segments prior to arterialization. Journal of Vascular Surgery 1984 1, 149-159DOI: (10.1016/0741-5214(84)90194-0) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 4 Basal and arachidonic acid—stimulated prostacyclin production by in situ—and reversed-treated human saphenous vein segments. Journal of Vascular Surgery 1984 1, 149-159DOI: (10.1016/0741-5214(84)90194-0) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 5 Luminal production of thromboxane B2 by in situ—and reversed-treated human saphenous vein segments. Journal of Vascular Surgery 1984 1, 149-159DOI: (10.1016/0741-5214(84)90194-0) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 6 Scanning electron microscopic study of luminal surface of a human in situ—treated saphenous vein segment. (×1000.) Journal of Vascular Surgery 1984 1, 149-159DOI: (10.1016/0741-5214(84)90194-0) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 7 Scanning electron microscopic study of luminal surface of a human reversed-treated saphenous vein segment. (×1000.) Journal of Vascular Surgery 1984 1, 149-159DOI: (10.1016/0741-5214(84)90194-0) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 8 Scanning electron microscopic study of luminal surface cell of a human reversed-treated saphenous vein segment. (× 4000.) Journal of Vascular Surgery 1984 1, 149-159DOI: (10.1016/0741-5214(84)90194-0) Copyright © 1984 Mosby, Inc. Terms and Conditions