Effects of patch or gel estrogen therapies on auditory brainstem response in surgically postmenopausal women: a prospective, randomized study Salvatore.

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Effects of patch or gel estrogen therapies on auditory brainstem response in surgically postmenopausal women: a prospective, randomized study Salvatore Caruso, M.D., Luigi Maiolino, M.D., Carmela Agnello, M.D., Aldo Garozzo, M.D., Lucia Di Mari, M.D., Agostino Serra, M.D. Fertility and Sterility Volume 79, Issue 3, Pages 556-561 (March 2003) DOI: 10.1016/S0015-0282(02)04763-5

FIGURE 1 Plasma E2 levels at baseline and during the third month of patch and gel estrogen treatment. Women taking estrogen therapy by patch or gel showed improved E2 values with respect to those at baseline (P<.001). Differences were not statistically significant between groups (*P = not significant). Data are expressed as mean ± SD. Caruso. Estrogen therapy and auditory brainstem response. Fertil Steril 2003. Fertility and Sterility 2003 79, 556-561DOI: (10.1016/S0015-0282(02)04763-5)

FIGURE 2 Latency time for auditory brainstem response: wave III latency. Surgically induced postmenopausal women treated with patch or gel estrogen therapy showed shorter auditory brainstem response thresholds than before treatment (P<.001). The acoustic stimuli were 100-dB sound pressure level peak emissions, alternated click at 11/s: 2000-stimuli presentation. Caruso. Estrogen therapy and auditory brainstem response. Fertil Steril 2003. Fertility and Sterility 2003 79, 556-561DOI: (10.1016/S0015-0282(02)04763-5)

FIGURE 3 Wave I, II, and V latencies and interpeak I–III, I–V, and III–V intervals in milliseconds before and during the third month of patch and gel ET. The women who were taking estrogen therapy had ABRs shorter than those at baseline (P<.001). Data are expressed as mean ± SEM. Caruso. Estrogen therapy and auditory brainstem response. Fertil Steril 2003. Fertility and Sterility 2003 79, 556-561DOI: (10.1016/S0015-0282(02)04763-5)