Ren-Ke Li, MD, PhD, Richard D. Weisel, MD, Donald A. G

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Autologous porcine heart cell transplantation improved heart function after a myocardial infarction Ren-Ke Li, MD, PhD, Richard D. Weisel, MD, Donald A.G. Mickle, MD, Zhi-Qiang Jia, MD, Eung-Joong Kim, MD, Tetsuro Sakai, MD, Shinji Tomita, MD, Leonard Schwartz, MD, Mark Iwanochko, MD, Mansoor Husain, MD, Robert J. Cusimano, MD, MSc, Robert J. Burns, MD, Terrence M. Yau, MD, MSc The Journal of Thoracic and Cardiovascular Surgery Volume 119, Issue 1, Pages 62-68 (January 2000) DOI: 10.1016/S0022-5223(00)70218-2 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Regional wall motion scores, evaluated by 2 cardiologists blinded to the treatment arm, in the infarct zone 4 weeks after either cell transplantation or injection of culture medium alone. Segmental wall motion was graded as –1, 0, 1, 2, 3, or 4, indicating dyskinesis and akinesis (–1 and 0, Bad ), varying levels of hypokinesis (1, 2, and 3, Intermediate ), and normal wall motion (3 and 4, Good ). Wall motion scores were significantly greater in the pigs receiving transplantation than in the control animals. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 62-68DOI: (10.1016/S0022-5223(00)70218-2) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Photomicrographs of representative sections from the infarct zones of (A) cell transplantation and (B) culture medium transplanted porcine hearts in which a LAD myocardial infarction was created. Control hearts demonstrated predominantly fibrous scar in the infarct zone, whereas transplanted hearts had greater cellularity (hematoxylin and eosin stain, original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 2000 119, 62-68DOI: (10.1016/S0022-5223(00)70218-2) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Photomicrograph of a section from a porcine heart in which 10% of the cultured heart cells had been prelabeled with BrdU in vitro before transplantation. Staining for BrdU was observed in cells throughout the infarct zone (arrows ), demonstrating some of the cells transplanted 4 weeks previously (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 2000 119, 62-68DOI: (10.1016/S0022-5223(00)70218-2) Copyright © 2000 Mosby, Inc. Terms and Conditions