Revisiting the Dutch hypothesis

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Presentation transcript:

Revisiting the Dutch hypothesis Dirkje S. Postma, MD, PhD, Scott T. Weiss, MD, PhD, Maarten van den Berge, MD, PhD, Huib A.M. Kerstjens, MD, PhD, Gerard H. Koppelman, MD, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 3, Pages 521-529 (September 2015) DOI: 10.1016/j.jaci.2015.06.018 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Cover of the first book on bronchitis, symposia on asthma and COPD, and their similarities and discrepancies held in Groningen as of 1960. This contained the foundation of the Dutch hypothesis. Journal of Allergy and Clinical Immunology 2015 136, 521-529DOI: (10.1016/j.jaci.2015.06.018) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Hypothetical tracking curves of FEV1 for a patient through life. The normal pattern of growth and decrease with age is shown by curve a. Significantly reduced FEV1 can develop through a normal rate of decrease after a reduced growth phase (curve b), through an early initiation of decrease after normal growth (curve c), or through an accelerated decrease after normal growth (curve d). Reproduced with permission from Rijcken.35 Journal of Allergy and Clinical Immunology 2015 136, 521-529DOI: (10.1016/j.jaci.2015.06.018) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Distribution of common phyla and genera in diseased and normal bronchi. A, Distribution of the phyla from sheathed bronchoscopic brushings of the left upper lobe for patients with asthma and COPD and healthy subjects subdivided into the 7 most frequent genera (Corynebacterium, Prevotella, Staphylococcus, Streptococcus, Veillonella, Haemophilus, and Neisseria). B, Distribution of the phyla from bronchoalveolar lavage fluid in children with difficult asthma and controls. Reproduced with permission from Hilty et al.54 Journal of Allergy and Clinical Immunology 2015 136, 521-529DOI: (10.1016/j.jaci.2015.06.018) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions