Combined Evaluation of Postoperative Serum Levels of Carcinoembryonic Antigen Less than or Equal to 2.5 ng/ml and Absence of Vascular Invasion may Predict.

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Presentation transcript:

Combined Evaluation of Postoperative Serum Levels of Carcinoembryonic Antigen Less than or Equal to 2.5 ng/ml and Absence of Vascular Invasion may Predict no Recurrence of Stage I Adenocarcinoma Lung Cancer Kosuke Kashiwabara, MD, Syoh Saeki, MD, Ji-ichiro Sasaki, MD, Masanobu Nomura, MD, Hirotsugu Kohrogi, MD Journal of Thoracic Oncology Volume 3, Issue 12, Pages 1416-1420 (December 2008) DOI: 10.1097/JTO.0b013e31818dda85 Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Chronological change of postoperative carcinoembryonic antigen (CEA) levels in p-stage I adenocarcinoma patients who had disease recurrence and no disease recurrence. R (−), absence of recurrence; R (+), presence of recurrence. Data are presented as mean ± SD (SD). *p < 0.05 versus the mean levels of serum CEA before surgery using the Mann-Whitney U test. Journal of Thoracic Oncology 2008 3, 1416-1420DOI: (10.1097/JTO.0b013e31818dda85) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Receiver operating characteristics (ROC) curves were constructed using the postoperative carcinoembryonic antigen (CEA) levels for a predictor of disease recurrence. Journal of Thoracic Oncology 2008 3, 1416-1420DOI: (10.1097/JTO.0b013e31818dda85) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 p values for comparison of 5-year recurrence free survival rates between in patients with high levels of postoperative carcinoembryonic antigen (CEA) and in patients with low levels of postoperative CEA using different cutoff values of postoperative CEA levels. Journal of Thoracic Oncology 2008 3, 1416-1420DOI: (10.1097/JTO.0b013e31818dda85) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Five-year recurrence survival rates in p-stage I adenocarcinoma patients with postoperative carcinoembryonic antigen (CEA) levels >2.5 ng/ml and in p-stage I adenocarcinoma patients with the levels ≤2.5 ng/ml. Journal of Thoracic Oncology 2008 3, 1416-1420DOI: (10.1097/JTO.0b013e31818dda85) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions