Effects of an Angiotensin II Antagonist on Ischemic and Nonischemic Isolated Rat Hearts Yosef Paz, Jacob Gurevitch, Inna Frolkis, Menachem Matsa, Amir.

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Effects of an Angiotensin II Antagonist on Ischemic and Nonischemic Isolated Rat Hearts Yosef Paz, Jacob Gurevitch, Inna Frolkis, Menachem Matsa, Amir Kramer, Chaim Locker, Rephael Mohr, Gad Keren The Annals of Thoracic Surgery Volume 65, Issue 2, Pages 474-479 (February 1998) DOI: 10.1016/S0003-4975(97)01234-4

Fig. 1 Hemodynamic performance of isolated rat hearts during 1 hour of perfusion: control group (white bars), hearts treated with low-dose losartan (dashed bars), and hearts treated with high-dose losartan (black bars). In spite of the gradual deterioration observed in the control group, hearts treated with high doses of losartan, but not with low doses, demonstrated a significantly better peak systolic pressure (A), dP/dt max (B), and pressure-time integral (C) compared with control hearts (p < 0.0001 for all hemodynamic parameters using analysis of variance). Results are presented as each heart’s percentage of baseline measurements. The Annals of Thoracic Surgery 1998 65, 474-479DOI: (10.1016/S0003-4975(97)01234-4)

Fig. 2 Before ischemia, the control group (white bars) and the high-dose losartan group (black bars) demonstrated similar hemodynamic performance (peak systolic pressure [A], dP/dt max [B], and pressure-time integral [C]). Results are presented as each heart’s percentage of baseline measurements. After ischemia, the control group demonstrated a significant deterioration in myocardial hemodynamics. Hearts treated with losartan exhibited improved recovery compared with control hearts (p < 0.0001 for all variables using analysis of variance). (Rep = reperfusion.) The Annals of Thoracic Surgery 1998 65, 474-479DOI: (10.1016/S0003-4975(97)01234-4)