Not all farming environments protect against the development of asthma and wheeze in children Markus Johannes Ege, MD, Remo Frei, MSc, Christian Bieli,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna.

Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children Markus Johannes.

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,

Ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk Tabea Brick, BA, Yvonne Schober, PhD, Christian Böcking, PhD, Juha.

Fatty acids, inflammation, and asthma

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study Georg Loss, MSc, Sondhja Bitter, MD, Johanna Wohlgensinger,

Georg Loss, PhD, Martin Depner, PhD, Laurien H. Ulfman, PhD, R. J

Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood Anna Lluis, PhD, Martin.

Markus J. Ege, MD, David P. Strachan, MD, William O. C. M

Atopic sensitization in the first year of life

Is 9 more than 2 also in allergic airway inflammation?

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna.

Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition

Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants Christoph Grüber, MD, PhD, Margriet van.

Fatty acids, inflammation, and asthma

Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: The PASTURE Study Petra Ina.

Prematurity, atopy, and childhood asthma in Puerto Ricans

Rising prevalence of asthma is sex-specific in a US farming population

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies.

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Reply Journal of Allergy and Clinical Immunology

Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts Olena Gruzieva, MD, PhD, Ulrike Gehring, PhD,

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

What are the best outcome measurements for atopic eczema

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy Piush J. Mandhane, MD, Justina M. Greene, Dip.

Karen C. Dannemiller, PhD, Janneane F. Gent, PhD, Brian P

Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children Markus Johannes.

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments Waltraud Eder, MD, Walt Klimecki, PhD, Lizhi Yu, MD, Erika.

Advances in the approach to the patient with food allergy

Geographic variability in childhood asthma prevalence in Chicago

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

The role of atopic sensitization in flexural eczema: Findings from the International Study of Asthma and Allergies in Childhood Phase Two Carsten Flohr,

Corinne A. Keet, MD, MS, Wayne G. Shreffler, MD, PhD, Roger D

Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study Mònica Guxens, MD, MPH, PhD, Agnes M.M. Sonnenschein–van.

One step forward, 2 steps back: The enigma of preschool wheeze

Prenatal exposure to a farm environment modifies atopic sensitization at birth Markus Johannes Ege, MD, Ileana Herzum, MD, Gisela Büchele, MPH, Susanne.

Development of atopic dermatitis according to age of onset and association with early- life exposures Caroline Roduit, MD, MPH, Remo Frei, PhD, Georg.

Reply Journal of Allergy and Clinical Immunology

Toll-like receptor 2 as a major gene for asthma in children of European farmers Waltraud Eder, MD, Walt Klimecki, PhD, Lizhi Yu, MD, Erika von Mutius,

Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health

Erika von Mutius, MD, MSc Journal of Allergy and Clinical Immunology

Day-care attendance, position in sibship, and early childhood wheezing: A population- based birth cohort study Nicolaos C. Nicolaou, MD, MPhil, Angela.

The relationship between vaccine refusal and self-report of atopic disease in children Rachel Enriquez, PhD, Whitney Addington, MD, Faith Davis, PhD,

Protection from childhood asthma and allergy in Alpine farm environments—the GABRIEL Advanced Studies Sabina Illi, PhD, Martin Depner, PhD, Jon Genuneit,

Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.

Measles and immunomodulation

Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children Kathrin Suttner, MSc, Martin Depner, MSc, Norman.

The protective effect of farm milk consumption on childhood asthma and atopy: The GABRIELA study Georg Loss, MSc, Silvia Apprich, PhD, Marco Waser, PhD,

Reply Journal of Allergy and Clinical Immunology

Increased food diversity in the first year of life is inversely associated with allergic diseases Caroline Roduit, MD, MPH, Remo Frei, PhD, Martin Depner,

Asthma: The past, future, environment, and costs

The environmental predictors of allergic disease

Exposure to a farming environment has allergen-specific protective effects on TH2- dependent isotype switching in response to common inhalants Debra A.

Environmental factors and eosinophilic esophagitis

Farming environments and childhood atopy, wheeze, lung function, and exhaled nitric oxide Oliver Fuchs, MD, Jon Genuneit, MD, Philipp Latzin, MD, PhD,

Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis Caroline Roduit, MD, MPH, Johanna.

Natural history of cow’s milk allergy

Presentation transcript:

Not all farming environments protect against the development of asthma and wheeze in children Markus Johannes Ege, MD, Remo Frei, MSc, Christian Bieli, MD, Dieneke Schram-Bijkerk, PhD, Marco Waser, PhD, Marcus R. Benz, MD, Gertraud Weiss, MPH, Fredrik Nyberg, MD, PhD, Marianne van Hage, MD, PhD, Göran Pershagen, MD, PhD, Bert Brunekreef, PhD, Josef Riedler, MD, Roger Lauener, MD, Charlotte Braun-Fahrländer, MD, Erika von Mutius, MD Journal of Allergy and Clinical Immunology Volume 119, Issue 5, Pages 1140-1147 (May 2007) DOI: 10.1016/j.jaci.2007.01.037 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Farm-related specific determinants of asthma, wheeze, and atopic sensitization. Mutually adjusted ORs with 95% CIs additionally adjusted for sex, study center, group, and family history of asthma are shown. Atopic sensitization was adjusted for sex, study center, family history of atopy, and additionally for maternal exposure to animal sheds during pregnancy. The models were established by using backward elimination based on Akaike's information criterion. Journal of Allergy and Clinical Immunology 2007 119, 1140-1147DOI: (10.1016/j.jaci.2007.01.037) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Farm-related specific determinants for atopic and nonatopic asthma. Mutually adjusted ORs with 95% CIs additionally adjusted for number of older siblings, sex, study center and family history of asthma, where appropriate, are shown. The models were established by using backward elimination based on Akaike's information criterion in the subsample of children selected for measurement of allergen-specific IgE levels. Journal of Allergy and Clinical Immunology 2007 119, 1140-1147DOI: (10.1016/j.jaci.2007.01.037) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Effects of microbial compounds measured in mattress dust on asthma, wheeze, and atopic sensitization. Mutually adjusted ORs with 95% CIs additionally adjusted for all variables contributing to the respective models in Fig 1 are shown. Journal of Allergy and Clinical Immunology 2007 119, 1140-1147DOI: (10.1016/j.jaci.2007.01.037) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Effect of being a farm child on asthma in agricultural and nonagricultural farms. Crude ORs are given with 95% CIs for asthma diagnosis dependent on being a farm child separately for the German subsample and the subsample of the 4 other countries. P values refer to Breslow-Day tests for homogeneity of effects. Journal of Allergy and Clinical Immunology 2007 119, 1140-1147DOI: (10.1016/j.jaci.2007.01.037) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions