Big Q: What role does DNA polymerase play in copying DNA? DNA Replication Big Q: What role does DNA polymerase play in copying DNA? Big Q: How does DNA replication differ in prokaryotic cells and eukaryotic cells?

Engage - Why do we copy? How can you make a copy of a page from the textbook? Why is it important to make an exact copy?

Explore - A perfect Copy Investigate the importance of making perfect copies *** Answer questions on your Inquiry Warm-Up Worksheet

Explain - DNA Replication Replication - DNA duplicates itself This takes place during the S-phase of interphase

Elaborate -Making new DNA Copying DNA DNA starts as a double-stranded molecule matching bases (A:T, C:G) then it unzips…

Explain - How does it unzip? Helicase - unwinds the double helix by breaking the hydrogen bonds between complimentary bases

Elaborate -DNA replication Strands “unzip” at the weak bonds between bases

Elaborate -DNA replication DNA bases in nucleus Enzyme DNA polymerase adds new bases proof reads DNA DNA polymerase

New copies of DNA Get 2 exact copies of DNA to split between new cells Template Strand DNA polymerase Complimentary Strand DNA polymerase

Explain - Telomeres Telomeres - tips of eukaryotic chromosomes that help prevent DNA damage during replication The enzyme telomerase adds telomeres to the chromosome In cancer cells, these segments do not shut off

Explore - Prokaryotic DNA Replication Proteins bind to DNA to trigger S phase Starts at a single point Proceeds in two direction until completion

Elaborate - Chapter Mystery UV Light Investigate how DNA replication is related to cancer ***Answer questions on your question sheet

Evaluate - DNA Replication Hand in your exit ticket upon exit