Observed (symbols) and predicted (solid lines, eq

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Observed (symbols) and predicted (solid lines, eq Observed (symbols) and predicted (solid lines, eq. 37) miotic effect (in millimeters) vs. biophase amount after three different doses of latanoprost (filled red circles, 0.1 µg; blue squares, 1.0 µg; and gray circles, 10 µg). Observed (symbols) and predicted (solid lines, eq. 37) miotic effect (in millimeters) vs. biophase amount after three different doses of latanoprost (filled red circles, 0.1 µg; blue squares, 1.0 µg; and gray circles, 10 µg). The observed effects are mean values with a coefficient of variation of approximately 30% for each observation. Johan Gabrielsson et al. Pharmacol Rev 2019;71:89-122 Copyright © 2018 by The Author(s)‏