FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort.

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Presentation transcript:

FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study Casper P. Hagen, M.D., Lise Aksglaede, Ph.D., Kaspar Sørensen, Ph.D., Annette Mouritsen, M.D., Mikkel G. Mieritz, M.D., Katharina M. Main, Ph.D., Jørgen Holm Petersen, Ph.D., Kristian Almstrup, Ph.D., Ewa Rajpert-De Meyts, Dm.S.C., Richard A. Anderson, Dm.S.C., Anders Juul, Dm.S.C. Fertility and Sterility Volume 100, Issue 4, Pages 1089-1095 (October 2013) DOI: 10.1016/j.fertnstert.2013.06.026 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Longitudinal prepubertal serum levels of FSH (IU/L) (A) and serum levels of AMH (pmol/L) (B) in 52 and 77 healthy girls, respectively. Individual serum levels of FSH and AMH are marked with dots and connected with thin lines (red: carriers of FSHB GG+FSHR AA, black: carriers of other combinations of genotypes). Fertility and Sterility 2013 100, 1089-1095DOI: (10.1016/j.fertnstert.2013.06.026) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 To evaluate which polymorphism contributed to the effect observed in the combined analysis, we isolated carriers of FSHB GG (A) and evaluated whether hormone levels differed depending on their FSHR carrier status (Mann-Whitney test); FSH (AA vs AG+GG), P = .04; AMH, P = .04. Conversely, we isolated FSHR AA carriers (B) and evaluated whether hormone levels differed depending on their FSHB carrier status; FSH (GG vs GT), P = .46; AMH, P = .05. Medians are marked by thick black lines; boxes indicate the 50th percentile; whiskers outline the range (nonoutliers); dots indicate values more than 1.5 times the interquartile range. red: carriers of FSHB GGþFSHR AA; and gray: carriers of other combinations of genotypes. Fertility and Sterility 2013 100, 1089-1095DOI: (10.1016/j.fertnstert.2013.06.026) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions