Microvascular density, vascular endothelial growth factor A, and its receptors in endometrial blood vessels in patients with menorrhagia Miriam Mints,

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Microvascular density, vascular endothelial growth factor A, and its receptors in endometrial blood vessels in patients with menorrhagia Miriam Mints, M.D., Bo Blomgren, M.D., Christian Falconer, M.D., Aino Fianu-Jonasson, M.D., Jan Palmblad, M.D. Fertility and Sterility Volume 84, Issue 3, Pages 692-700 (September 2005) DOI: 10.1016/j.fertnstert.2005.03.065 Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Micrographs of immunohistochemical staining of VEGF-A, VEGFR-1, and VEGFR-2 in menorrhagic endometrium. Arrows point to vessel structures. G = glands. Scale bars are shown within panels. Mints. VEGF and menorrhagia. Fertil Steril 2005. Fertility and Sterility 2005 84, 692-700DOI: (10.1016/j.fertnstert.2005.03.065) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Double staining for VEGF-A and CD34 by confocal microscopy in the fluorescent mode. The two stains: (a) green for VEGF-A and (b) red for CD34 were co-localized (resulting in yellow color) in the endothelial cells, which (c) surround the lumen of a capillary (c). Mints. VEGF and menorrhagia. Fertil Steril 2005. Fertility and Sterility 2005 84, 692-700DOI: (10.1016/j.fertnstert.2005.03.065) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 The expression of VEGF-A and its receptors VEGFR-1 and VEGFR-2 in capillaries in menorrhagia patients and healthy controls in endometrial sections. Data are given as median values and the 95% confidence interval for stained vessels. The bars denote the median values, and shaded areas represent the 95% confidence interval. Patients and controls in the secretory phase are depicted with filled symbols and in proliferative phase with open symbols. Patients are denoted with P, and controls with C. Mints. VEGF and menorrhagia. Fertil Steril 2005. Fertility and Sterility 2005 84, 692-700DOI: (10.1016/j.fertnstert.2005.03.065) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions