Sox2β-geo expression (X-gal staining, blue) in neural and forebrain development and in adult neural stem cells from Sox2β-geo/+ mice. Sox2β-geo expression.

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Sox2β-geo expression (X-gal staining, blue) in neural and forebrain development and in adult neural stem cells from Sox2β-geo/+ mice. Sox2β-geo expression (X-gal staining, blue) in neural and forebrain development and in adult neural stem cells from Sox2β-geo/+ mice. (A) Undifferentiated ES cells; (B) E7.5 neural plate stage. Right, anterior; left, posterior. A few blue cells are also visible at the base of the allantois, where the first appearance of primordial germ cells has been described. (C) E12.5 embryo; (D-G) coronal sections of forebrain at E11.5 (D), E12.5 (E) and E17.5 (F,G). In F, asterisks indicate developing thalamic nuclei, basolateral (more external) and centromedian and paraventricular (closer to the midline); black circle indicates the striatum. In G, the black arrowhead indicates the choroid plexus. GE, ganglionic eminence; LV, lateral ventricle. (H-Q) Adult brain. (H) Sagittal section with anterior to the left and posterior to the right. Brief X-gal reaction development. Note the intensely stained ventricle lining and rostral migratory stream. (I,J) Coronal sections (I is more posterior than J) after a prolonged X-gal reaction development. Asterisk and black arrowheads, thalamic nuclei; black circle, dorsal striatum; white circle, septum. (K,L) Interference contrast microscope view of lateral ventricle wall showing details from a section corresponding to that shown in J. Black arrow, ependymal staining; white arrows, subependymal staining. (M) Thalamic region detail, at a level slightly posterior to that shown in I (and corresponding to that shown in F; see F, I and J for symbols). (N) Hippocampus dentate gyrus (long X-gal reaction development). Arrows indicate the germinative layer; asterisks indicate the granule cell layer. (O) Neurospheres, the progeny of stem cells, grown in vitro from adult brain lateral ventricles in the presence of G418 for 5-12 passages (about 5-12 weeks) express lacZ in most cells. (P,Q) Cells obtained by differentiation of the clonal progeny of a single G418-resistant (i.e. Sox2 expressing) cell were probed with antibodies against (P) β-tubulin III (neurones; red) and GFAP (astroglia; green), or (Q) GalC (oligodendroglia). Anna L. M. Ferri et al. Development 2004;131:3805-3819 © 2004.