α-Cells mainly express SSTR2 and SSTR3 α-Cells mainly express SSTR2 and SSTR3. mRNA expression of glucagon and insulin (A) and SSTR1–5 (B) relative to GAPDH was assessed by quantitative PCR in FACS-sorted α- and β-cells from GYY and RIPYY mice, respectively. α-Cells mainly express SSTR2 and SSTR3. mRNA expression of glucagon and insulin (A) and SSTR1–5 (B) relative to GAPDH was assessed by quantitative PCR in FACS-sorted α- and β-cells from GYY and RIPYY mice, respectively. Data are presented as the mean ± SE for three experiments from different cell populations. **P < 0.01 and ***P < 0.001 for comparisons between α- and β-cells. Bao-Khanh Lai et al. Diabetes 2018;67:2239-2253 ©2018 by American Diabetes Association