Sox2 regulates dental epithelial stem cell proliferation and differentiation. Sox2 regulates dental epithelial stem cell proliferation and differentiation.

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Sox2 regulates dental epithelial stem cell proliferation and differentiation. Sox2 regulates dental epithelial stem cell proliferation and differentiation. (A-B″) Immunofluorescence staining of the proliferation marker Ki67 in sagittal sections of E16.5 Sox2F/F and Sox2cKO mouse incisors. (A′,B′) High magnification view of red boxed regions in A and B to show the proliferation in the LaCL (outlined). (A″,B″) High magnification view of white boxed regions in A and B to show the proliferation in the LiCL (outlined). (C) Quantification of the ratio of Ki67-positive cells to total cells in the cervical loops. Mean±s.e.m., n=3. (D-F) Progenitor cell differentiation measured using two different labels (CldU and IdU), which were injected and measured after 24 h and 1 h, respectively. The red label-retaining cells (CldU) mark differentiated cells and the green label-retaining cells (IdU) mark recently mitotic cells. The arrows indicate the region of neural vascular bundles. The LaCLs are highlighted by yellow dashed boxes. (D′-D‴,E′-E‴) Higher magnifications of the white boxed areas in D and E, respectively, highlight the progenitor cells at the distal tip of the incisors. DI, distal; PR, proximal. (F) Quantification of CldU+ cells in the epithelial tissue of the white boxed region shown in D′ and E′. Mean±s.e.m., n=3. Scale bars: 100 μm. Zhao Sun et al. Development 2016;143:4115-4126 © 2016. Published by The Company of Biologists Ltd