Schematic diagram that summarizes the findings of the current study showing that diabetes-induced peroxynitrite inactivates the NGF/TrkA receptor prosurvival.

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Schematic diagram that summarizes the findings of the current study showing that diabetes-induced peroxynitrite inactivates the NGF/TrkA receptor prosurvival signal via tyrosine nitration. Schematic diagram that summarizes the findings of the current study showing that diabetes-induced peroxynitrite inactivates the NGF/TrkA receptor prosurvival signal via tyrosine nitration. Instead, diabetes-induced peroxynitrite activates the NGF/p75NTR proapoptotic signal leading to neuronal death. Treatments that target peroxynitrite formation or tyrosine nitration represent potentially effective therapeutics in attenuating retinal neurodegenerative diseases. Tayyeba K. Ali et al. Diabetes 2008;57:889-898 ©2008 by American Diabetes Association