Phenotype of the AH series 29 weeks after Cdx2 knock out and beyond.

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Phenotype of the AH series 29 weeks after Cdx2 knock out and beyond. Phenotype of the AH series 29 weeks after Cdx2 knock out and beyond. (A) (a) Haematoxylin and Eosin montage through the polyp-containing caecal region. Scale bar: 1 mm. (b,c) Adjacent sections showing absence of Cdx2 staining (b) and secretion of pepsinogen C in the same region (c). Scale bars: 500 μm. (d) Staining of a formalin-fixed section for β-catenin shows no evidence of nuclear localisation. Scale bar: 50 μm. (B) (i) Normal adult antral mucosa showing expression of Sox2, (ii) constitutional ablation of Cdx2 (Cdx2+/ko) showing Sox2 expression in heterotopic polyp next to normal Sox2 negative colon and (iii) conditional ablation of Cdx2 in AH series showing absence of Sox2 expression in caecal polyp. Scale bars: 250 μm. (C) RT-PCR of AH experimental versus control caecum 62 weeks post Cdx2 knock out. The experimental caecum contained a large polyp but did not express Barx1. Embryonic and adult stomach controls. (D) Jejunal region stained with AB-PAS and showing excessive development of Paneth cells within Cdx2-positive regions, copious magenta mucous secretion and PAS-positive subepithelial cysts. Scale bars: 100 μm. A formalin-fixed section stained for lysozyme confirms the excessive numbers of Paneth cells present. (E) Electron micrograph of normal Paneth cells 29 weeks after knock out showing abundance of healthy secretory granules. Scale bar: 5 μm. Emma J. Stringer et al. Development 2012;139:465-474 © 2012.