Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis Joohee Lee, AB, David Seto, BA, Leonard Bielory,

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Presentation transcript:

Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis Joohee Lee, AB, David Seto, BA, Leonard Bielory, MD Journal of Allergy and Clinical Immunology Volume 121, Issue 1, Pages 116-121.e11 (January 2008) DOI: 10.1016/j.jaci.2007.10.043 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flowchart of process of study selection for meta-analysis. Journal of Allergy and Clinical Immunology 2008 121, 116-121.e11DOI: (10.1016/j.jaci.2007.10.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Pooled statistical analyses of primary and secondary prevention trials using RevMan. Prevention studies were assessed by using both FE and RE models of relative risk. The treatment studies were assessed in terms of intragroup and intergroup SCORAD change also using both models of WMD. Studies are ordered from top to bottom in descending order of MQ quality ranking. Journal of Allergy and Clinical Immunology 2008 121, 116-121.e11DOI: (10.1016/j.jaci.2007.10.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Ranking list of prevention and treatment clinical trials using Cho & Bero's MQ scale. Fisher analysis of ranking results from the 4 quality scales indicated that this scale had the best interobserver and interscale reliability. The quartile status allows gauging of the relative quality of these 2 interventional approaches. Boldface studies are those that were meta-analyzed. Journal of Allergy and Clinical Immunology 2008 121, 116-121.e11DOI: (10.1016/j.jaci.2007.10.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance. Journal of Allergy and Clinical Immunology 2008 121, 116-121.e11DOI: (10.1016/j.jaci.2007.10.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance. Journal of Allergy and Clinical Immunology 2008 121, 116-121.e11DOI: (10.1016/j.jaci.2007.10.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance. Journal of Allergy and Clinical Immunology 2008 121, 116-121.e11DOI: (10.1016/j.jaci.2007.10.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance. Journal of Allergy and Clinical Immunology 2008 121, 116-121.e11DOI: (10.1016/j.jaci.2007.10.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Kappa values indicate that the Cho & Bero MQ scale is superior to the other 3 scales in terms of interobserver and interscale concordance. Journal of Allergy and Clinical Immunology 2008 121, 116-121.e11DOI: (10.1016/j.jaci.2007.10.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions