Effect of the acute administration of benzylamine plus vanadate on oral glucose tolerance test in STZ-induced diabetic rats. Effect of the acute administration.

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Materials and Methods Phase 1 Evaluated acute effects on fasting blood glucose and on post-oral glucose Groups 1 and 3 received distilled water Groups.

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Effect of the acute administration of benzylamine plus vanadate on oral glucose tolerance test in STZ-induced diabetic rats. Effect of the acute administration of benzylamine plus vanadate on oral glucose tolerance test in STZ-induced diabetic rats. A: Relative changes in glycemia with an oral glucose load (2 g/kg) starting 15 min after intravenous injection of vehicle (⧫) or 20 μmol/kg vanadate + 7 μmol/kg benzylamine (□). Results are expressed as increments in plasma glucose. B: Integrated increase in glycemia. Concentrations of plasma glucose at time zero were 21.1 ± 1.2, 23.1 ± 2.3, 23.2 ± 3.9, 21.2 ± 1.3, and 26.2 ± 1.1 mmol/l in diabetic rats untreated (PBS) or treated with vanadate (V), benzylamine (Benz), Benz + V, and Benz + V + semicarbazide (SCZ), respectively. Data are means ± SE of 4–15 observations expressed as percentage, with 100% corresponding to the PBS group. *A significant difference versus PBS group at P < 0.05. Luc Marti et al. Diabetes 2001;50:2061-2068 ©2001 by American Diabetes Association