The complex field of interplay between vasoactive agents

Slides:

Advertisements

Similar presentations

Visceral Muscle. How is the gut organized anatomically?

Advertisements

General Shape of a Smooth Muscle Cell

Navdeep Tangri, Paul V.J. Komenda, Claudio Rigatto

A simplified diagram of smooth muscle contraction and the site of action of calcium channel-blocking drugs. Contraction is triggered (red arrows) by influx.

Melamine toxicity: one more culprit in calcium kidney lithiasis

What does the following have in common?

Volume 4, Issue 3, Pages (June 2006)

How do we critically use long-acting muscarinic receptor antagonists and beta- adrenergic receptor agonists monotherapy, or these combination therapies.

HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half

Volume 82, Issue 1, Pages 7-8 (July 2012)

Mitchell H. Rosner, W. Kline Bolton Kidney International

Volume 66, Issue 5, Pages (November 2004)

Volume 71, Issue 11, Pages (June 2007)

Effect of Benidipine in Human Internal Mammary Artery and Clinical Implications Hai-Tao Hou, BE, Jun Wang, BA, Zheng-Qing Wang, MD, Xiao-Cheng Liu, MD,

ESA and iron therapy in chronic kidney disease: a balance between patient safety and hemoglobin target Szu-Chun Hung, Der-Cherng Tarng Kidney International

Ding Ai, John Y.-J. Shyy, Yi Zhu Kidney International

Angiotensin II-induced growth of vascular smooth muscle cells requires an Src- dependent activation of the epidermal growth factor receptor1 Dirk Bokemeyer,

Volume 58, Issue 1, Pages (July 2000)

Volume 85, Issue 3, Pages (March 2014)

Mark S Taylor, A.Marie McMahon, Jason D Gardner, Joseph N Benoit

Chapter 14 Blood Pressure – Regulation and Pathology

Volume 87, Issue 2, Pages (February 2015)

Volume 74, Issue 3, Pages (August 2008)

The new role of calcimimetics as vasculotropic agents

Punit Yadav, Nelson Leung, Paul W. Sanders, Paul Cockwell

RhoA/Rho-Kinase: Pathophysiologic and Therapeutic Implications in Gastrointestinal Smooth Muscle Tone and Relaxation Satish Rattan, Benjamin R. Phillips,

Let's look at cysts from both sides now

Joseph F. Clark, Gail Pyne-Geithman Pathophysiology

Live Longer sans the AT1A Receptor

Guo-Wei He, MD, DSc, David P. Taggart, FRCS

Volume 87, Issue 2, Pages (February 2015)

Thomas Quaschning, Jan Galle, Christoph Wanner

Nirupama Ramkumar, Donald E. Kohan Kidney International

Bisphosphonate safety and efficacy in chronic kidney disease

Volume 70, Issue 10, Pages (November 2006)

Volume 83, Issue 5, Pages (May 2013)

Melamine toxicity: one more culprit in calcium kidney lithiasis

Osteopontin in diabetic nephropathy: signpost or road?

Volume 86, Issue 2, Pages (August 2014)

Heme oxygenase: protective enzyme or portal hypertensive molecule?

Angiotensin-(1–7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells Z. Su, J. Zimpelmann, K.D. Burns Kidney.

Navdeep Tangri, Paul V.J. Komenda, Claudio Rigatto

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Calcium sensing in podocytes

Nephrology Crossword: Glomerulonephritis

Volume 57, Issue 1, Pages (January 2000)

Susan K. Fellner, William J. Arendshorst Kidney International

Volume 71, Issue 11, Pages (June 2007)

Volume 82, Issue 9, Pages (November 2012)

G proteins and hypertension: An alternative candidate gene approach

Organ transplantation goes to the movies

Nanocrystals seed calcification in more ways than one

The vascular secret of Klotho

Molecular mechanisms of renal hypertrophy: Role of p27Kip1

Eric N. Johnson, PhD, Kirk M. Druey, MD

Volume 80, Issue 10, Pages (November 2011)

Is complement a target for therapy in renal disease?

Volume 70, Issue 3, Pages (August 2006)

Targeting TNF-α: A novel therapeutic approach for asthma

Volume 74, Issue 9, Pages (November 2008)

Gene targeting: Applications in transplantation research

Editorial II British Journal of Anaesthesia

Cell biological and physicochemical aspects of arterial calcification

Prevention of vascular calcification with bisphosphonates without affecting bone mineralization: a new challenge? Ellen G. Neven, Marc E. De Broe, Patrick.

Volume 74, Issue 10, Pages (November 2008)

Volume 76, Issue 9, Pages (November 2009)

Volume 87, Issue 3, Pages (September 2004)

Rho and Rac Take Center Stage

Spasm in Arterial Grafts in Coronary Artery Bypass Grafting Surgery

Presentation transcript:

The complex field of interplay between vasoactive agents Pernille B. Hansen Kidney International Volume 76, Issue 9, Pages 929-931 (November 2009) DOI: 10.1038/ki.2009.335 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Interaction between α-adrenoceptors and angiotensin II receptors. Stimulation of α-adrenoceptors by norepinephrine (NE) leads to increased calcium sensitivity in the afferent arteriole through phosphorylation of myosin phosphatase target subunit 1 (MYPT1). This inhibits myosin light chain phosphatase (MLCP) activity and increases the level of phosphorylated myosin light chain (MLC), increasing the contractility and calcium sensitivity of the afferent arteriole in response to angiotensin II (Ang II). This could potentially occur through a phospholipase C (PLC)-dependent and Rho kinase–dependent pathway. CaM, calmodulin; IP3, inositol triphosphate; MLCK, myosin light chain kinase; PP1c, type 1 protein phosphatase; VSMC, vascular smooth-muscle cell. Kidney International 2009 76, 929-931DOI: (10.1038/ki.2009.335) Copyright © 2009 International Society of Nephrology Terms and Conditions