Tracking Neurons In A Free-Moving Caenorhabditis Elegans Kirillova Irina, 15124
Aim The aim is to study automatic tracking neurons in a moving and deforming brain of C.elegans.
Outline of the presentation Introduction. Automatic tracking neurons in a moving and deforming brain. Results and Conclusion. References.
What is C.elegans? Caenorhabditis elegans is a free-leaving, transparent nematode about 1 mm in length.
Topicality Why is C.elegans interesting for research? Because human body is very complicated, and it's hard to study. At the same time we can consider this worm as a single cell that exhibits a lot of interesting features which are similar to human’s, often named as "fundamental mysteries of modern biology".
Automatic tracking neurons in a moving and deforming brain
Algorithm
Centerline Detection
Straightening and Segmentation
Registration Vector Construction
Clustering Clustering similar registration vectors allows for the identification of that particular neuron across time.
Error Correction This is done by finding the TPS transformation, ut→t⋆: Xt ↦ Xt⋆, that maps the identified points from Xt to the corresponding points in Xt⋆ excluding the point s.
Results and Conclusion This method represents a fully automated algorithm for segmenting and tracking neuron in freely behaving C.elegans. This new approach works better than all previous techniques.
References. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436637/ https://cbs.umn.edu/cgc/what-c-elegans https://en.wikipedia.org/wiki/Caenorhabditis_elegans https://www.labroots.com/trending/neuroscience/7060/tiny-worm-discovery
Thank you for attention!