Histamine Journal of Allergy and Clinical Immunology

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Presentation transcript:

Histamine Journal of Allergy and Clinical Immunology Donald MacGlashan, Jr, MD, PhD Journal of Allergy and Clinical Immunology Volume 112, Issue 4, Pages S53-S59 (October 2003) DOI: 10.1016/S0091-6749(03)01877-3

FIG 1 Tissue and inflammatory cells in the airway. A simplified representation of a tissue mucosal interface is shown, including both resident cells and migrating leukocytes. A, Distribution of histamine receptors (any subclass, H1-H4); B, receptors for IL-3; and C, receptors for IL-4. Dark gray signifies the presence of a receptor (for human cells only); white signifies no current evidence of a receptor; light gray signifies either that it has not yet been examined or that it might be induced. Mø, Macrophage; EPI, epithelial cell; MC, mast cell; EC, endothelial cell; Ba, basophil; Eo, eosinophil; N, neutrophil; Mo, monocyte; T, T cells; B, B cells; DC, dendritic cells; F, fibroblasts; SM, smooth muscle cells; G, gland cells (undefined); N, nerves. Journal of Allergy and Clinical Immunology 2003 112, S53-S59DOI: (10.1016/S0091-6749(03)01877-3)

FIG 2 Effect of desloratadine on IL-4 and histamine secretion from human basophils stimulated with an optimal concentration of anti-IgE antibody (n = 5). Histamine release in the absence of drug was 40% ± 6%, and IL-4 release was 403 ± 207 pg/106 basophils. Cells were incubated with or without drug for 15 minutes before stimulation. Adapted with permission from Schroeder JT, Schleimer RP, Lichtenstein LM, Kreutner W. Inhibition of cytokine generation and mediator release in human basophils treated with desloratadine. Clin Exp Allergy 2001;31:1369-77.43 Journal of Allergy and Clinical Immunology 2003 112, S53-S59DOI: (10.1016/S0091-6749(03)01877-3)

FIG 3 Effect of azelastine on the cytosolic calcium response or on histamine release from basophils or mast cells stimulated with an optimal concentration of anti-IgE antibody. Cells were labeled with fura-2 and analyzed for free cytosolic calcium by digital microscopy. The average net calcium elevation for the first 15 minutes of the reaction was determined from a field of 30 to 100 cells. For cells treated without azelastine, dimethyl sulfoxide at a relevant concentration was used as a control. Histamine release was determined from the supernatants obtained from the microscope chamber from which the calcium measurements were made. A, Basophil studies (0.5 μg/mL anti-IgE antibody); B, purified human lung mast-cell studies (3 μg/mL anti-IgE antibody). Journal of Allergy and Clinical Immunology 2003 112, S53-S59DOI: (10.1016/S0091-6749(03)01877-3)

FIG 4 Idealized representation of mediator release kinetics from human basophils. The 3 major classes of mediators are represented: histamine (preformed), LTC4 (newly generated without protein synthesis), and IL-4 (newly generated with protein synthesis). Journal of Allergy and Clinical Immunology 2003 112, S53-S59DOI: (10.1016/S0091-6749(03)01877-3)

FIG 5 Effect of cimetidine (10 μmol/L) on histamine or IL-4 secretion from human basophils stimulated with an optimal concentration of anti-IgE antibody (n = 2). Cimetidine (or control vehicle) was added 10 minutes before stimulation. IL-4 and histamine were measured 4 hours later. Journal of Allergy and Clinical Immunology 2003 112, S53-S59DOI: (10.1016/S0091-6749(03)01877-3)