Fig. 1. PARN is differentially expressed in breast cancer versus non-cancerous tissue/cells. PARN is differentially expressed in breast cancer versus non-cancerous.

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Fig. 1. PARN is differentially expressed in breast cancer versus non-cancerous tissue/cells. PARN is differentially expressed in breast cancer versus non-cancerous tissue/cells. (A,B) Analysis of PARN (A) and PLD2 (B) expression in human breast cancer versus normal adjacent tissue using microarray data from the Finak Breast Dataset (Finak et al., 2008). See Materials and Methods for details. (C,D) Gene expression of PARN (C) or PLD2 (D) in COS-7 and MCF-7 cell lines. Quantitative RT-PCR results in C,D are normalized to the averaged results of the three housekeeping genes used: GAPDH, Actin, and TBP (TATA-binding protein). Data presented as bars are means+s.e.m. Experiments were performed in technical triplicates (for qRT-PCR assays) for n=5 independent experiments. The difference between means was assessed by single-factor ANOVA.) *P<0.05, significant increase between samples and controls; #P<0.05, significant decrease between samples and controls. Taylor E. Miller, and Julian Gomez-Cambronero Biology Open 2017;6:176-186 © 2017. Published by The Company of Biologists Ltd