Body mass index trajectory classes and incident asthma in childhood: Results from 8 European Birth Cohorts—a Global Allergy and Asthma European Network.

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Body mass index trajectory classes and incident asthma in childhood: Results from 8 European Birth Cohorts—a Global Allergy and Asthma European Network initiative Peter Rzehak, PhD, Alet H. Wijga, PhD, Thomas Keil, MD, MSc, Esben Eller, PhD, Carsten Bindslev-Jensen, MD, PhD, Henriette A. Smit, PhD, Joost Weyler, MD, PhD, Sandra Dom, MSc, Jordi Sunyer, MD, PhD, Michelle Mendez, PhD, Maties Torrent, MD, Oriol Vall, MD, Carl-Peter Bauer, MD, Dietrich Berdel, MD, Beate Schaaf, MD, Chih-Mei Chen, PhD, Anna Bergström, PhD, Maria P. Fantini, MD, Monique Mommers, PhD, Ulrich Wahn, MD, Susanne Lau, MD, Joachim Heinrich, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 6, Pages 1528-1536.e13 (June 2013) DOI: 10.1016/j.jaci.2013.01.001 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Sex-adjusted longitudinal BMI profile classes estimated by using growth mixture modeling. Bars indicate 95% CIs around the estimated trajectory class means. Class 1, Normative growth; Class 2, rapid growth only up to 2 years of age; Class 3, persistent rapid growth up to 6 years of age. Journal of Allergy and Clinical Immunology 2013 131, 1528-1536.e13DOI: (10.1016/j.jaci.2013.01.001) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Specified LGMM to identify BMI-SDS trajectory classes (schematic). Analyses were restricted to those 5 cohorts with BMI measurements at age 2 years. Included studies were as follows: GINIplus, LISAplus, MAS, PIAMA-NHS, and AMICS-Barcelona. Journal of Allergy and Clinical Immunology 2013 131, 1528-1536.e13DOI: (10.1016/j.jaci.2013.01.001) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Sex-adjusted longitudinal BMI profile classes estimated by using growth mixture modeling (model restricted to those 5 cohorts with BMI measurement at age 2 years). Bars indicate 95% CIs around the estimated trajectory class means. Class 1, Normative growth; Class 2, rapid growth only up to 2 years of age; and Class 3, persistent rapid growth up to 6 years of age. Journal of Allergy and Clinical Immunology 2013 131, 1528-1536.e13DOI: (10.1016/j.jaci.2013.01.001) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions