Tumor location determines response to intravenous FOLFIRINOX chemotherapy. Tumor location determines response to intravenous FOLFIRINOX chemotherapy. (A)

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Tumor location determines response to intravenous FOLFIRINOX chemotherapy. Tumor location determines response to intravenous FOLFIRINOX chemotherapy. (A) Mice treated with FOLFIRINOX lost similar amounts of weight regardless of tumor location (n=8 per experimental group; error bars represent mean±s.d.). (B) FOLFIRINOX treatment resulted in significant reduction in orthotopic tumor volume, though no difference was observed with heterotopic tumors. (C) Representative gross images (in situ and explanted) of orthotopic (solid blue lines) and heterotopic tumors with and without FOLFIRINOX treatment. (D) Representative immunofluorescent staining for cleaved caspase-3; caspase expression is significantly increased in orthotopic but not heterotopic tumors. (E) There was no difference in tumor platinum level 2 h after FOLFIRINOX tail vein injection, suggesting similar levels of drug penetration between orthotopic and heterotopic tumors. (F) FOLFIRINOX treatment was associated with reductions in local tumor invasion and metastatic disease. 4× magnification was used for all immunofluorescent images. *P<0.05, **P<0.01; ns, nonsignificant. Derek J. Erstad et al. Dis. Model. Mech. 2018;11:dmm034793 © 2018. Published by The Company of Biologists Ltd