CDKN2A: The IVS2-105A/G Intronic Mutation Found in an Italian Patient Affected by Eight Primary Melanomas Silvia Majore, Caterina Catricalà, Francesco.

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CDKN2A: The IVS2-105A/G Intronic Mutation Found in an Italian Patient Affected by Eight Primary Melanomas Silvia Majore, Caterina Catricalà, Francesco Binni, Paola De Simone, Laura Eibenschutz, Paola Grammatico Journal of Investigative Dermatology Volume 122, Issue 2, Pages 450-451 (February 2004) DOI: 10.1046/j.0022-202X.2004.22222.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Patient's family pedigree. The patient (proband) is individual III:2. His cousin (III:5) died at age 28 from lung metastasis of unknown origin. Genotypes are shown below various individuals, with CDKN2A genotype above and MC1R below. Journal of Investigative Dermatology 2004 122, 450-451DOI: (10.1046/j.0022-202X.2004.22222.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Chromatogram showing the IVS2-105A/G CDKN2A variant. The heterozygous A/G peak is easily detected. Journal of Investigative Dermatology 2004 122, 450-451DOI: (10.1046/j.0022-202X.2004.22222.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions