Failure to Detect Differences in Proliferation Status of Nevi from CDKN2A Mutation Carriers and Non-Carriers  Scott R. Florell, Kenneth M. Boucher, Joseph A. Holden, Laurence J. Meyer, Wolfram E. Samlowski, Lisa A. Cannon-Albright, John J. Zone, Sancy A. Leachman  Journal of Investigative Dermatology  Volume 118, Issue 2, Pages 386-387 (February 2002) DOI: 10.1046/j.1523-1747.2002.01659.x Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Average topo II proliferation index among nevi (N) in CDKN2A carriers and noncarriers. One melanoma in situ (MIS) from a carrier showed a topo II index of 7.2%. The right half of this figure shows the averages or weighted averages of the proliferation indices from nevi (Smolle et al, 1989;Moretti et al, 1990;Rudolph et al, 1997) melanoma in situ (Rudolph et al, 1997), primary melanomas (PM;Smolle et al 1989;Moretti et al, 1990;Rudolph et al, 1998;Grossman et al, 1999), and metastatic melanomas (MM;Smolle et al 1989;Moretti et al, 1990;Grossman et al, 1999). These proliferation indices were determined by Ki-67 immunostaining. Journal of Investigative Dermatology 2002 118, 386-387DOI: (10.1046/j.1523-1747.2002.01659.x) Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions