Efficacy and tolerability of antiasthma herbal medicine intervention in adult patients with moderate-severe allergic asthma Ming-Chun Wen, MD, Chun-Hua.

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Efficacy and tolerability of antiasthma herbal medicine intervention in adult patients with moderate-severe allergic asthma Ming-Chun Wen, MD, Chun-Hua Wei, MD, Zhao-Qiu Hu, MD, MS, Kamal Srivastava, MPhil, Jimmy Ko, MD, Su-Ting Xi, MD, MS, Dong- Zhen Mu, MD, MS, Ji-Bin Du, MD, Guo-Hua Li, MD, Sylvan Wallenstein, PhD, Hugh Sampson, MD, Meyer Kattan, MD, Xiu-Min Li, MD Journal of Allergy and Clinical Immunology Volume 116, Issue 3, Pages 517-524 (September 2005) DOI: 10.1016/j.jaci.2005.05.029 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Effect of treatment with (A) ASHMI or (B) prednisone on symptom scores. Average daily symptom scores were evaluated over a 1-week period before treatment to establish a baseline (week 0). The effect of treatment on symptom scores was evaluated by analyzing average daily symptom scores in weeks 1, 2, 3, and 4 of treatment. ∗∗∗P < .001. Journal of Allergy and Clinical Immunology 2005 116, 517-524DOI: (10.1016/j.jaci.2005.05.029) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Effect of 4 weeks of treatment with ASHMI or prednisone on (A) FEV1, (B) PEF, or (C) β-agonist use. ∗∗∗P < .001. Journal of Allergy and Clinical Immunology 2005 116, 517-524DOI: (10.1016/j.jaci.2005.05.029) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Effect of 4 weeks of treatment with ASHMI or prednisone on eosinophil numbers in peripheral blood. ∗∗∗P < .001. Journal of Allergy and Clinical Immunology 2005 116, 517-524DOI: (10.1016/j.jaci.2005.05.029) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Effect of 4 weeks of treatment with ASHMI or prednisone on serum cortisol levels (7:30-8:30 AM) determined by radioimmunoassay. Data are means ± SDs. ∗∗∗P < .001. Journal of Allergy and Clinical Immunology 2005 116, 517-524DOI: (10.1016/j.jaci.2005.05.029) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 Effect of 4 weeks of treatment with ASHMI or prednisone on (A) serum IgE titers, (B) IL-13, (C) IL-5, and (D) IFN-γ as determined by ELISA. Data are medians (A) or means ± SDs (B-D). ∗∗∗P < .001. Journal of Allergy and Clinical Immunology 2005 116, 517-524DOI: (10.1016/j.jaci.2005.05.029) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions