Thomas Münzel et al. JACC 2018;71:

Slides:

Advertisements

Similar presentations

Text 1 Biochemistry of Glucose Damage in Diabetes.

Advertisements

Oxidative Stress and Diabetes Jian Li Beijing Institute of Geriatrics Ministry of Health.

Nitric Oxide Synthase Cody A Scholtens CHE /21/14.

FasDR (CD95) in many cancers, in particular Non-Hodgkin’s Lymphoma Benjamin Badger.

Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Cardiovascular Abnormalities in Sickle Cell Disease.

Date of download: 6/25/2016 Copyright © The American College of Cardiology. All rights reserved. From: Myocardial Microvascular Inflammatory Endothelial.

Revised curriculum (1) December 16 (Tuesday) Second messengers

Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion Babu V Naidu, FRCS, Steven M Woolley, MRCS, Alexander S Farivar,

Immune pathogenesis of apoptosis of CD34 multipotential hematopoietic cells in acquired aplastic anemia. Antigens are presented to T lymphocytes by antigen-presenting.

Copyright © 2003 American Medical Association. All rights reserved.

Natural history of thoracic aortic aneurysms

From: Narrative Review: The Emerging Clinical Implications of the Role of Aldosterone in the Metabolic Syndrome and Resistant Hypertension Ann Intern Med.

FIGURE 1: Plasma levels of indoxyl sulfate (IS) in four groups: Sham, Sham + AST-120, CKD and CKD + AST-120 mice (n = 12 for each group). Data are expressed.

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

by Renato D. Lopes, John D. Horowitz, David A. Garcia, Mark A

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Bart Staels, PhD The American Journal of Medicine

Important pathophysiologic mechanisms in HF (1)

Natural history of thoracic aortic aneurysms

T. Vescovo, G. Refolo, G. Vitagliano, G.M. Fimia, M. Piacentini

Prevention of ischemia-reperfusion injury in cardiac surgery: Therapeutic strategies targeting signaling pathways Kay Maeda, MD, PhD, Marc Ruel, MD,

Volume 151, Issue 2, Pages (February 2017)

Figure 3 Mechanisms by which oestradiol reduces

Free Radicals in Medicine. II. Involvement in Human Disease*

Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion Babu V Naidu, FRCS, Steven M Woolley, MRCS, Alexander S Farivar,

Nat. Rev. Endocrinol. doi: /nrendo

Volume 151, Issue 2, Pages (February 2017)

The marriage of glucose and blood vessels: It isn’t all that sweet

Volume 78, Issue 9, Pages (November 2010)

Michael G. Katz, MD, PhD, Elizabeth Brandon-Warner, PhD, Anthony S

Nat. Rev. Cardiol. doi: /nrcardio

Divya Gupta et al. JCHF 2013;1:

Signalling pathways in alcohol-induced liver inflammation

Metformin: From Mechanisms of Action to Therapies

Evaluation of the microcirculation in vascular disease

Overexpression of transforming growth factor–β1 correlates with increased synthesis of nitric oxide synthase in varicose veins Theresa Jacob, PhD, Anil.

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease Stacey Ruiz, Pablo E. Pergola, Richard.

Figure 4 Mechanisms of leptin function on kidney injury

A “Reductionist” View of Cardiomyopathy

Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions Batya B. Davidovici, Naveed Sattar,

Advances in the Treatment of Sickle Cell Disease

Disparate effects of single endothelin-A and -B receptor blocker therapy on the progression of renal injury in advanced renovascular disease Alejandro.

Chapter 14 Blood Pressure – Regulation and Pathology

Chapter 25 Analysis of Gene Expression

Volume 87, Issue 2, Pages (February 2015)

Volume 76, Issue 11, Pages (December 2009)

Ioannis Smyrnias et al. JACC 2019;73:

Volume 70, Issue 10, Pages (November 2006)

The molecular mechanisms of hemodialysis vascular access failure

Fig. 3 Chronic work overload leads to mitochondrial calcium overload.

Eberhard Schulz, and Thomas Münzel JACC 2008;52:

Nitric Oxide in Human Skin: Current Status and Future Prospects

Figure 3 Underlying mechanisms of TREG cells in atherosclerosis

Volume 81, Issue 8, Pages (April 2012)

Molecular mechanisms of renal hypertrophy: Role of p27Kip1

Constantijn Franssen et al. JCHF 2016;4:

Fig. 3 Chronic work overload leads to mitochondrial calcium overload.

Thomas Münzel et al. JACC 2018;71:

Alternatively activated macrophages as therapeutic agents for kidney disease: in vivo stability is a key factor Senthilkumar Alagesan, Matthew D. Griffin

Metformin: From Mechanisms of Action to Therapies

The Management of Diabetic Neuropathy in CKD

Schematic diagram of mechanisms of stroke-induced immunosuppression with NK cells as an example. Schematic diagram of mechanisms of stroke-induced immunosuppression.

Damage-associated molecular pattern (DAMP)-induced activation of Toll-like receptors (TLRs). Damage-associated molecular pattern (DAMP)-induced activation.

Postulated impact of SLE on endothelial nitric oxide (NO) synthase activity and endothelial nitric oxide synthase (eNOS) uncoupling. Postulated impact.

Thomas Münzel et al. JACC 2017;70:

Yiannis S. Chatzizisis et al. JACC 2007;49:

Wolbachia-induced responses of specific cell types.

Comparison of key events involved in normal parturition and inflammation-induced parturition. Comparison of key events involved in normal parturition and.

General overview of innate and adaptive immune responses to and regulation of black yeasts. General overview of innate and adaptive immune responses to.

Cyclooxygenase (COX) independent chemopreventive mechanisms of non-steroidal anti-inflammatory drugs (NSAIDs). *Genes with a T cell factor 4 responsive.

Presentation transcript:

Thomas Münzel et al. JACC 2018;71:688-697 Proposed Pathophysiological Mechanisms of Noise-Induced Cardiometabolic Disease Noise causes annoyance and stress responses characterized by activation of the hypothalamic-pituitary-adrenal axis, inflammation, thrombosis, and altered gene expression. See text, section “Potential (molecular) mechanisms underlying noise-induced cardiovascular disease,” for details. Modified/combined from Münzel et al. (73) with permission of the publisher. Copyright © 2017, Oxford University Press. Ang II = angiotensin II; AT1 = angiotensin receptor type 1; ATM = ataxia telangiectasia mutated; eNOS = endothelial nitric oxide synthase; Fas = cell death signaling molecule (CD95); FOXO = Forkhead box O; HPA = hypothalamic-pituitary-adrenal; iNOS = inducible nitric oxide synthase; NADPH = nicotinamide adenine dinucleotide phosphate; Nox = NADPH oxidase; NO = nitric oxide; O2 = oxygen; TGF = transforming growth factor. Thomas Münzel et al. JACC 2018;71:688-697 2018 The Authors