Regulating the Regulators: Routing the Wnt-β-Catenin–Lef Signals Randall B. Widelitz, PhD  Journal of Investigative Dermatology  Volume 123, Issue 2, Pages viii-x (August 2004) DOI: 10.1111/j.0022-202X.2004.23239.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Co-activator competition for β-catenin can route cell fate.β-Catenin can directly interact with several competing transcriptional co-activators which preferentially transcribe different downstream genes. Here this is depicted as a traffic circle with pathways diverging in different directions based on the co-activator associated with β-catenin. In this scenario, the relative levels of expression of these important regulatory molecules can route cells towards alternative fates. Therefore it is important to study how these regulators are themselves regulated. Journal of Investigative Dermatology 2004 123, viii-xDOI: (10.1111/j.0022-202X.2004.23239.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions