MTORC1 regulates basal GLUT4 protein expression independent of VWR exercise. mTORC1 regulates basal GLUT4 protein expression independent of VWR exercise.

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Strategies for differential inhibition of mTORC1 and mTORC2 with rapamycin. Strategies for differential inhibition of mTORC1 and mTORC2 with rapamycin.

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mTORC1 regulates basal GLUT4 protein expression independent of VWR exercise. mTORC1 regulates basal GLUT4 protein expression independent of VWR exercise. Data for rapamycin-treated lean mice. A: Representative immunoblots for relative GLUT4, phospho-S6K, phospho-4E-BP1, and tubulin. B: Quantity of GLUT4 protein determined by densitometry and Glut4 mRNA determined by qRT-PCR. C and D: Right-side quadriceps muscle weight (C) and total accumulated running distance (D) for mice treated with rapamycin. n = 3 animals/group. Data are mean ± SEM. †P < 0.05, VWR effect; ‡P < 0.05, rapamycin treatment effect. QUAD, quadriceps; RAPA, rapamycin treated; SED, sedentary; VEH, vehicle treated. Jami M. Gurley et al. Diabetes 2016;65:2911-2919 ©2016 by American Diabetes Association