A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis Peng Jin, BM, MSc, Anand.

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A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis Peng Jin, BM, MSc, Anand Kumar Andiappan, PhD, Jia Min Quek, BSc, Bernett Lee, PhD, Bijin Au, BSc, Yang Yie Sio, BSc, Astrid Irwanto, PhD, Claudia Schurmann, PhD, Hans Jörgen Grabe, MD, Bani Kaur Suri, PhD, Sri Anusha Matta, BSc, Harm-Jan Westra, PhD, Lude Franke, PhD, Tonu Esko, PhD, Liangdan Sun, PhD, Xuejun Zhang, PhD, Hong Liu, PhD, Furen Zhang, PhD, Anis Larbi, PhD, Xin Xu, MD, PhD, Michael Poidinger, PhD, Jianjun Liu, PhD, Fook Tim Chew, PhD, Olaf Rotzschke, PhD, Li Shi, MD, PhD, De Yun Wang, MD, PhD Journal of Allergy and Clinical Immunology Volume 135, Issue 6, Pages 1486-1493.e8 (June 2015) DOI: 10.1016/j.jaci.2014.12.1870 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 BDNF protein levels (in picograms per milliliter) in cell lysates (A) and supernatants (B) of HEK293T cells in vitro. Cells, Untransfected HEK293T cells with no vector; Mock, untransfected cells with the empty vector; MT, Met/mutant variant; WT, wild-type/Val variant. *P < .05, Student t test. Journal of Allergy and Clinical Immunology 2015 135, 1486-1493.e8DOI: (10.1016/j.jaci.2014.12.1870) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 BDNF plasma levels (in picograms per milliliter) in healthy subjects, as measured by means of ELISA and stratified according to rs6265 genotype. A Kruskal-Wallis test was initially used to test whether the different genotypes were associated with altered BDNF protein levels in plasma. Pairwise Mann-Whitney tests were then carried out to determine whether there were significant differences in BDNF levels between genotypes. ∗P < .05. Journal of Allergy and Clinical Immunology 2015 135, 1486-1493.e8DOI: (10.1016/j.jaci.2014.12.1870) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Total IgE levels in sera from healthy subjects, as measured by using ImmunoCAP and stratified according to rs6265 genotype. The Kruskal-Wallis test was initially used to test whether the different genotypes were associated with altered plasma IgE levels. The pairwise Mann-Whitney test were then carried out to determine whether there were significant differences in IgE levels between genotypes. ∗P < .05. Journal of Allergy and Clinical Immunology 2015 135, 1486-1493.e8DOI: (10.1016/j.jaci.2014.12.1870) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Linkage disequilibrium plot generated by using Haploview for the BDNF gene locus. Journal of Allergy and Clinical Immunology 2015 135, 1486-1493.e8DOI: (10.1016/j.jaci.2014.12.1870) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 A representative plot of normalized expression of BDNF (probe ID: 510746) stratified according to rs10767664 (A) and rs6265 (B) genotype in the SHIP-TREND cohort. Journal of Allergy and Clinical Immunology 2015 135, 1486-1493.e8DOI: (10.1016/j.jaci.2014.12.1870) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions