Pharmacology American Journal of Kidney Diseases

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Presentation transcript:

Pharmacology American Journal of Kidney Diseases Mark A. Perazella, MD, Chirag Parikh, MD, PhD American Journal of Kidney Diseases Volume 46, Issue 6, Pages 1129-1139 (December 2005) DOI: 10.1053/j.ajkd.2005.07.051 Copyright © 2005 National Kidney Foundation, Inc. Terms and Conditions

Fig 1 Schematic model of renal proximal tubule with organic anion and cation transporters. Both endogenous substances and drugs are secreted and reabsorbed by these transporters. Patients with renal failure may develop toxicity due to competition for these pathways of secretion due to endogenous substances and medications that compete for these transporters (see text). Abbreviations: OA, organic anion; OC, organic cation; OAT, OA transporter; OCT, OC transporter; PEPT 1/2, peptide transporters 1 and 2; MRP2, multidrug-resistant transporter. American Journal of Kidney Diseases 2005 46, 1129-1139DOI: (10.1053/j.ajkd.2005.07.051) Copyright © 2005 National Kidney Foundation, Inc. Terms and Conditions